Interleukin-4 (IL-4) is a multifunctional cytokine that plays a critical role in apoptosis, differentiation and proliferation. The intensity of IL4 response depends upon binding to its receptor, IL-4R. The therapeutic efficiency of interleukins can be increased by generating structural mutants having greater stability. In the present work, attempts were made to increase the stability of human I...

! #"%$& ' () Finding a centre point is a fundamental problem of geometry. The Euclidean centre, or centre of the smallest enclosing sphere, provides a natural definition for the centre of a set of points. As shown in [BBKS00] and [DK04], the Euclidean centre of a set of points * + -, is unstable; small perturbations at only a few points of can result in an arbitrarily large relative change in t...

Convection cannot be explicitly resolved in general circulation models given their typical grid size of 50 km or larger. However, by multiplying the vertical acceleration in the equation of motion by a constant larger than unity, the horizontal scale of convection can be increased at will, without necessarily affecting the larger-scale flow. The resulting hypohydrostatic system has been recogni...

The aim of the study was to evaluate intra- and intersession test-retest reliability for the measurements of centre of pressure displacement in quiet standing and during maximal voluntary body leaning (approximate area of stability limits). 27 elderly men participated in the study (71.4±4.9 of age). Intrasession (4 measurements with two-minute breaks) and intersession (4 measurements one week a...

background: initiating a national poisoning information centre (pic) in estonia took about 12 years of challenging work on research, training and attracting governmental support and funding. in this study we described the establishment process and the profile of phone calls in the first year which the pic started to be available full time (24h/day 7days/week).  methods: this was a descriptive r...

Relevance/Impact The control of human gait and the maintenance of balance depend upon the complex integration of visual, vestibular and somatosensory information. Dysfunction of any of these components can result in deficits in the body’s ability to maintain equilibrium of the centre of mass by counteracting the constant destabilising forces that challenge it. The role of vision in the control ...

BACKGROUND Falls amongst older people have been linked to reduced postural stability and slowed movement responses. The objective of this study was to examine differences in postural stability and the speed of response between young adults, low fall-risk older adults, and high fall-risk older adults during voluntary postural sway movements. METHODS Twenty-five young adults (25+/-4 years), and...

We discuss long-time behaviour of the Hele-Shaw flow in R with surface tension and injection or suction in the origin, for domains that are small perturbations of balls. After rescaling, radially symmetric solutions become stationary. We study the stability of these solutions. In particular, we show that all liquid can be removed by suction if the suction point and the geometric centre coincide...